The temporal profiles of the acute Per2-Luc/HSE-SLR surge (Figure S2A) and circadian Per2-Luc (Figure S2B) (5 mM H2O2 for 10 min; Period = 26.0 h, Robustness = 57.5%, Acrophase = 35.84 h, SD in Acrophase = 0.0872) demonstrate resetting by OS at similar optimal doses in U2OS:Per2-Luc/HSE-SLR, human osteosarcoma U2OS cells harboring Per2-Luc and HSE-SLR. This evidence concerns the gene PER2 and osteosarcoma.