We found 38 genes had both high scores and significant GO terms in those 30 genes are known SLE genes and the same is clearly represented as a Venn diagram Figure: 1 and the details of the predicted genes are given in the Table: 2.Thus we were able to identify 8 genes as novel SLE candidate genes such as HSP90B1, IGF1R, PDGFRA, PDGFRB, SOCS3, TIRAP and YWHAZ. Here, HSP90B1 is linked to systemic lupus erythematosus.