In similar populations of patients, Truong et al reported that a >25% nodal ratio, medially located tumors, and ER-negative hormone receptor status predicted for increased risk of LRR [10], Yang et al found ER-negative tumors to be of greatest predictive value in their cohort [12], and Cheng et al suggest that only tumor size is significant for LRR [30]. This evidence concerns the gene NR4A1 and neoplasm.