Recent in vitro analyses have suggested that RhoC may mediate cancer cell invasion via control of other molecules, such as formin (FMNL2 [10] and FMNL3 [11]) at lamellipodia or through spatial resolution of RhoC at invadopodia [12] or, possibly, via upstream regulators such as Notch-1 [6], mir10b [3], p38γ-mediated RhoC ubiquitination [13] or RhoGDP dissociation inhibitor α (RhoGDIα) [14]. The gene discussed is RHOC; the disease is cancer.