APOE and hyperlipidemia: In fact, in the case of hyperlipidemia, three database instances linking the disease with young mice (5 to 16 weeks of age) used a mouse model involving low-density lipoprotein (LDL) receptor-deficient mice [25]–[27] while two instances linking hyperlipidemia with older mice (27 to 64 weeks of age) involved ApoE deficient/knockout mice [28],[29].