Despite that APOE gene polymorphism is known to be associated with Pick's disease [11]–[13], very few studies have examined a potential role of apoE in Pick's disease with the exception of Hayashi et al., who demonstrated the presence of apoE immunoreactivity in Pick bodies from two cases with the APOE genotypes of 3/4 and 3/3, respectively [14]. This evidence concerns the gene APOE and frontotemporal dementia.