We predicted at the outset that we would observe very little staining with the nApoECF antibody in those 3/3 cases based on our previous findings in the AD brain [7], but instead observed nApoECF staining within Pick bodies in two APOE 3/3 cases, with the third case (Case #5) being the exception. The gene discussed is APOE; the disease is Alzheimer disease.