Although the role of tumor-infiltrating B cells is still not clear, it is suggested that activated B cells may contribute to an anti-tumor immune response by secretion of antigen-specific antibodies, induction of innate immune cells (e.g. M1 tumor-associated macrophages), release of distinct cytokines (e.g. IL-6) and activation of complement cascades [13], [43]. Here, IL6 is linked to neoplasm.