Univariable and multivariable associations between 1 SD increase of the level of log GDF-15 and 10 years outcome concerning total mortality, cardiovascular mortality (CVD), coronary heart disease mortality or morbidity (CHD), stroke mortality or morbidity and the composite of the former events (values are hazard ratios (95 % CI) and p values). The gene discussed is GDF15; the disease is Stroke.