The major findings of this study are: (i) Egg derived bioactive tri-peptide IRW significantly attenuated established hypertension in adult male SHRs, (ii) IRW treatment increased eNOS expression and increased NO-mediated vasorelaxation, (iii) IRW treatment attenuated plasma Ang II levels and ameliorated markers of inflammation, oxidative/nitrosative stress and fibrosis in SHR animals. This evidence concerns the gene AGT and hypertensive disorder.