Anderson et al found that soy isoflavone intake in adulthood was not associated with risk of breast cancer for any receptor type (ER+/PR+, ER-/PR-, or ER+/PR-), but did find that higher intake during adolescence was associated with lower odds of the mixed receptor type: AOR 0.77, 95%CI 0.60-0.99 [41]. This evidence concerns the gene ESR1 and breast cancer.