Both genotypes exhibited SICs (Figure 5A); however, consistent with elevated spontaneous astrocytic activity, Tg2576 mice exhibited increased SIC frequency as well (0.16 ± 0.045 SICs/min, n=20; 0.34 ± 0.10 SICs/min, n=22, P<0.0001 K-S); possibly a result of α7 nAChR up-regulation previously reported for this AD model [34,35]. This evidence concerns the gene CHRNA7 and Alzheimer disease.