In view of the above findings showing a stimulatory role for VEGF, PKC δ, mTOR, HIF-1α, and PI3K/Akt pathway in the mechanism of allergic inflammatory response, we sought to determine whether there is cross-talk between these stimulatory pathways leading to a tight regulation of AHR and airway inflammation in a murine model of asthma. Here, AKT1 is linked to asthma.