As soluble mIL-15/IL-15Rα was detected from murine neuroblastoma (Neuro-2a) and glioma (GL261, CT-2A) cell lines following J100D infection, this virus can be utilized to study the combined effects of oHSV and mIL-15/IL-15Rα in multiple tumor models. This evidence concerns the gene IL15RA and central nervous system cancer.