Since we recently demonstrated that PAR-2 contributes to heart remodeling after cardiac ischemia/reperfusion injury [20] and that activation of PAR-2 leads to hypertrophic growth of cardiomyocytes in vitro[15], we investigated if cardiomyocyte-specific overexpression of PAR-2 induced heart hypertrophy and HF in mice. This evidence concerns the gene F2RL1 and cardiac hypertrophy.