F2RL1 and hydrops fetalis: Since we recently demonstrated that PAR-2 contributes to heart remodeling after cardiac ischemia/reperfusion injury [20] and that activation of PAR-2 leads to hypertrophic growth of cardiomyocytes in vitro[15], we investigated if cardiomyocyte-specific overexpression of PAR-2 induced heart hypertrophy and HF in mice.