Since we have previously shown that PAR-2 deficiency had no effect on the topography of heart coronary vessels and the size of the area at risk in a mouse model of ischemia/reperfusion injury [20], we expect that permanent occlusion of LAD artery should result in the similar initial myocardial infarction in both PAR-2+/+ and PAR-2−/− mice, caused by ischemia. The gene discussed is F2RL1; the disease is ischemia.