PPARs participate in mediating metabolic disorders via downstream genes which are important for adipocyte maturation, lipid accumulation, and insulin-sensitive glucose transport, including PGC1-α, PGC1-β, aP2, LPL, ACC, ACO, CD36, UCP-2 and Glut4 [18], [42], [54]. Here, UCP2 is linked to metabolic disease.