To investigate the effect of CXCR4 on the ability of RhoE to function in the metastasis of gastric cancer, we enhanced the expression of CRCR4 in SGC7901-M-siRhoE cells by lentiviral tranduction and down-regulated its expression in SGC7901-NM-RhoE cells by siRNA interference. The gene discussed is RND3; the disease is gastric cancer.