As Figure S3A shown, neither up- regulation of RhoE in SGC7901-NM cells nor down-regulation of RhoE in SGC7901-M cells could cause marked change of cell proliferation (p > 0.05), thus excluded the effect of RhoE on cell proliferation which would bring confusion to our results and further confirmed that RhoE can promote cell motility of gastric cancer cells. Here, RND3 is linked to gastric cancer.