Beyond the neuropsychological assessment which still represents the most essential tool for AD and mild cognitive impairment (MCI) screening in humans[2], the most reputed biomarkers for AD are cerebral-spinal fluid (CSF) Aβ42 and phosphorylated-tau protein levels, hippocampal volume measured by magnetic resonance imaging (MRI) techniques and positron electronic tomography (PET) scan with brain Aβ radiotracers. Here, MAPT is linked to Alzheimer disease.