AKT1 and non-small cell lung carcinoma: For instance, low miR-126 expression was observed in non-small cell lung cancer and identified as unfavorable prognostic factor in non-small cell lung cancer patients [13]; miR-126 expression was also decreased in human breast cancer, and may play roles in tumorigenesis and growth by regulating the vascular endothelial growth factor/phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway [14].