TARDBP and amyotrophic lateral sclerosis: In this study, we demonstrate that ER stress leads to accumulation of both wildtype and ALS-linked TDP-43 mutants in the cytoplasm and to incorporation of TDP-43 into cytoplasmic SGs, We also demonstrate that C-terminal TDP-43 inclusions, induced by proteasome inhibition, are closely associated with PDI and the ER-Golgi compartments, suggesting potential disturbances to these organelles in TDP-43-linked disease.