KCNN4 and renal fibrosis: Since KCa3.1 blockade or genetic deletion of the channel has previously been reported to inhibit fibroblast proliferation and to reduce interstitial collagen deposition in a model of renal fibrosis [20], we postulated that KCa3.1 blockade might also be able to reduce the collagen deposition and often constrictive adventitial and media fibrosis that typically accompanies chronic AV [1].