Similar TRAM-34 plasma concentrations have also previously been found to prevent atherosclerosis development in ApoE−/− mice through a combination of suppressing VSMC proliferation and decreasing infiltration of macrophages and T cells into atherosclerotic plaques [21] supporting our assumption that higher concentrations of KCa3.1 inhibitors “hit” both the fibroproliferative and the inflammatory component of AV. Here, KCNN4 is linked to atherosclerosis.