ELFN1 and epilepsy: With the exception of homozygous mutants in an Adam23 knockout mouse line [63], [64], which interacts with known epilepsy gene LGI1[23], [65], spontaneous seizures have never been observed in any of our mice in the facility over the last ten years (>30,000 mice, compared to 176 Elfn1 homozygous mutants) or in over 60 lines assayed in a prior research project [63].