On the other hand, two different gene mutations could influence each other and result in one disease: for example, Desmoglein-2 and Desmocollin-2 mutations have been reported to cause arrhythmogenic right ventricular dysplasia/cardiomyopathy [35]; a OGG1 mutation in combination with a MUTYH mutation reportedly led to hereditary colorectal cancer [36]; and NEK1 and DYNC2H1 mutations resulted in short rib polydactyly, Majewski type [37]. This evidence concerns the gene DSC2 and familial colorectal cancer.