Molecular studies on the development of PPROM have been undertaken [10], with a focus on genes that are involved with inflammation [11]–[14], including TNFα [15]–[17], FAS, which is member 6 gene of the tumor necrosis factor receptor superfamily [9], [18], and Toll-like receptor (TLR) [19], [20]. Here, TNF is linked to preterm premature rupture of the membranes.