Figure 4H–I shows that while benign normal appearing epithelium (basal and luminal cells, although mostly luminal cells are visible) expresses GSTP1, the cribriform PIN/CIS lesions showed marked reductions in staining. This reduced GSTP1 staining in non-invasive cribriform neoplastic lesions was also reported by Borowsky et al. [41] and in a recently described CYP1A-humanized mouse model [53]. The gene discussed is GSTP1; the disease is in situ carcinoma.