PHIP and in situ carcinoma: When the extent of cribiform PIN/CIS was compared in only those animals that survived to the end of study (52 weeks), the number of lesions per ventral prostate was reduced to 1.0 per rat fed tomato + broccoli + PhIP compared to rats fed PhIP-alone which had 2.5 lesions per ventral prostate, p = 0.017 (Figure 3A).