However, since there is little biologic difference between KIR2DL2 and KIR2DL3 (KIR2DL2 and KIR2DL3 are alleles of the same locus with the same HLA ligand) and C1C1-2DL3 has no effect on onset age of HCC (P = 0.81, Table 3), it seems more plausible that the activating KIR2DS2 is the biologically relevant predictor. This evidence concerns the gene KIR2DL3 and hepatocellular carcinoma.