PEBP1 and breast carcinoma: miR-224 was recently shown to target Raf kinase inhibitor protein (RKIP), a tumor suppressor that protects against metastasis and genomic instability, and to have a positive effect on Transwell migration, 3D growth in Matrigel, and wound healing in breast cancer cell lines, probably through RKIP target genes, notably MMP1 (Huang et al., 2012).