Enrichment analysis of the burden test of genes from tumor samples (relapse vs. relapse-free) resulted in several immune-related and inflammatory pathways, including: innate immune response (p = 0.0024); neutrophil degranulation (p = 0.0052); inflammatory response (p = 0.0056); negative regulation of interferon-alpha biosynthetic process (p = 0.016); positive regulation of chemokine (C-C motif) ligand 5 production (p = 0.016); interferon-gamma-mediated signaling pathway (p = 0.035); and positive regulation of interleukin-8 production (p = 0.037). The gene discussed is CXCL8; the disease is neoplasm.