This disease is associated with seizures, intellectual disability, and autism, and is the result of heterozygous mutations in the genes encoding TSC1 or TSC2, which encode proteins that together form a complex that regulates activity of the mammalian Target of Rapamycin (mTOR), a well-known regulator of mRNA translation (Zeng et al., 2008; Curatolo and Moavero, 2012; Ryther and Wong, 2012; Talos et al., 2012). The gene discussed is MTOR; the disease is autism.