PRRT2 and Alzheimer disease: Since there is also evidence suggesting that the loss of Wingless/Wnt signaling is involved in AD (Boonen et al., 2009; Lucas et al., 2001; Jackson et al., 2002; Sofola et al., 2010), understanding how the non-canonical NFull–PKC signaling, the canonical Notch signaling, and Wingless/Wnt signaling function together in LTM formation might help us understand memory formation and memory loss upon neurodegeneration.