The functions of the Notch, PKC, and CREB genes are disrupted in many neurodegenerative diseases, including Alzheimer’s disease (AD; Wang et al., 1994; Pakaski et al., 2002; Costa et al., 2003; Selkoe and Kopan, 2003; Pugazhenthi et al., 2011). This evidence concerns the gene CREB1 and Alzheimer disease.