VAPB and amyotrophic lateral sclerosis: Interestingly, a mutation in vesicle-associated membrane protein-associated protein B (VAPB), an ER-associated transmembrane protein that has been shown to interact with a key ER stress regulator, ATF6, has been identified as the familial ALS gene, ALS8 (Gkogkas et al., 2008; Nishimura et al., 2004).