Furthermore, because aging represents the single greatest risk factor for ALS and other neurodegenerative diseases, it is therefore significant that SOD1 G85R locomotion defects are improved by mutants or RNAi versus select targets in the daf-2/insulin-like signaling and aging regulatory pathway of C. elegans (Boccitto et al., 2012). This evidence concerns the gene INS and neurodegenerative disease.