SUFU and medulloblastoma: SUFU is a tumour suppressor protein that is found to be inactivated most frequently (up to 50%) by germline mutations in children below the age of three presenting with medulloblastoma of the desmoplastic/nodular subtype (Slade et al., 2011 ▶; Brugières et al., 2012 ▶), whereas a somatic mutation frequency of about 10% has been reported for sporadic medulloblastomas of the desmoplastic subtype (Taylor et al., 2002 ▶).