Additionally, downregulation of SRC-3 by siRNA led to increased sensitivity of cancer cells to cytotoxic agent-induced apoptosis through many signaling pathways, such as reduced nuclear factor kappa B (NF-κB)-mediated transcription, depressed expression of apoptosis inhibitor bcl-2, increased production of mitochondrial apoptotic factors (caspases-9 and caspases-7), enhanced AKT signaling and p38 kinase activities [8–10]. This evidence concerns the gene NCOA3 and cancer.