Our analysis successfully identified the clinically relevant genomic signatures in three cases: i) Identification of synthetic genes that have stage-associated genomic features, ii) Identification of the IDH1 gene from GBM mutation data and iii) identification of methylation on MLH1 and mutations on TGFBR2 for MSI status of CRC. The gene discussed is TGFBR2; the disease is colorectal carcinoma.