KRAS and metastatic neoplasm: Among 7 L-L patients, ORR was 86% (α 0.05, CI ± 28) (see Supplementary material, Table 4, which describes activity, efficacy, and effectiveness of FIr-B/FOx regimen according to KRAS genotype and extension of metastatic disease); 3 performed liver metastasectomies (43%) and 3 cCRs (43%) in patients who did not undergo liver surgery and showed PFS of 78+, 69+, and 49+ months; median PFS was 30 months (3–78+ months); median OS was not reached (20–78+ months) at a median follow-up of 49 months.