TSPAN1 and head and neck squamous cell carcinoma: Huang et al. showed a MK-induced NET-1 pathway contributing to migration/invasiveness of human head and neck squamous cell carcinoma cells then found RNAi silencing of NET-1 dramatically decreased MK-induced expression of MMP-2, which demonstrated the role of NET-1(TSPAN1) as one of various signaling components [31].