Antitumor drugs like cantharidin control cell cycle and induce apoptosis by inhibiting PP2A [85], and cell viability inhibition and proapoptotic effect of cantharidin in PANC-1 pancreatic cancer is mediated by the PP2A/IκB kinase (IKKα)/IκBα/p65 NF-κB pathway [86]. Here, NFKBIA is linked to familial pancreatic carcinoma.