MMP14 and cancer: Since HOXD10 has been shown to directly regulate the transcription of MMP-14, which plays a crucial role in cancer cell invasion, we further determined the protein expression of MMP-14 in U251 and U87 cells transfected with miR-23a mimic or miR-23a inhibitor, or co-transfected with miR-23a inhibitor and HOXD10 siRNA.