Like H19, KNCQ1OT1 is also located at 11p15.5, paternally imprinted, and its over-expression is associated with cancer progression, increased proliferation, and the overgrowth disorder Beckwith-Wiedemann Syndrome (BWS) via the inhibition of p57 expression [57,58]. This evidence concerns the gene CDKN1C and Beckwith-Wiedemann syndrome.