LMNA and Hutchinson-Gilford progeria syndrome: In this study, we used our previously published mouse model with epidermal expression of the HGPS mutation LMNA c.1824C>T that replicates several features of the HGPS skin phenotype (Sagelius et al., 2008), to explore the effects of lamin A and progerin expression during murine embryogenesis and test the hypothesis that high levels of the common progeroid mutation during development would result in a more severe phenotype with similarities to RD (Fig. 1A).