FLCN and renal cell carcinoma: Although ACHN cell line was not derived from a BHD patient and we would not expect that silencing FCLN with siRNA in ACHN cell line would replicate a RCC cell line derived from a BHD patient, our study did show consistent results between UOK257 and ACHN cells in respect to paclitaxel treatment-induced apoptosis and autophagy in the presence or absence of FLCN.