We found that IL8, CXCL1, IL1B, CXCL3, CCL2, CXCL3, CXCL2 and ICAM1 genes, all of which are known to be involved in the acute inflammatory response, were the most up-regulated genes in BMSCs co-cultured with leukemia cells (Table 1). This evidence concerns the gene CXCL1 and leukemia.