Induction of cell death was associated with activation of c-Jun-N-terminal kinase (JNK) in DU145 but not in LnCaP cells [13] or with formation of ROS in PC3 and LnCaP, but was independent of ROS in HepG2 and multiple myeloma cells [12,25,26]. The gene discussed is MAPK8; the disease is plasma cell myeloma.