Intriguingly, NCOA3 can act as a co-activator also of PPARs[23] and was found to inhibit TP53 in breast cancer cells[39] implicating a broader involvement of NCOA3 in regulation of PLAC1. Thus, additional studies are required to dissect the complex regulation of PLAC1 in placenta and cancer tissues. Here, TP53 is linked to cancer.