Intriguingly, NCOA3 can act as a co-activator also of PPARs[23] and was found to inhibit TP53 in breast cancer cells[39] implicating a broader involvement of NCOA3 in regulation of PLAC1. Thus, additional studies are required to dissect the complex regulation of PLAC1 in placenta and cancer tissues. The gene discussed is NCOA3; the disease is cancer.