ERBB2 and head and neck squamous cell carcinoma: In a review study in 2001, Quon et al. indicated that high expression levels of EGFR and HER2/neu are prognostic markers which correlate with poor clinical outcome in patients with HNSCC (36).By contrast, in a case review study in 2009 by Tse et al. HER2 was associated with longer survival in node-positive patients (37).