Reports on the role of the HER2/neu proto-oncogene product in HNSCC are less conclusive than those detailing the role of EGFR(HER1), as over-expression of HER2/neu has been shown to be present in anywhere from only a few to all HNSCC specimens investigated and correlations with clinical parameters are controversial (23-26). The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.