Aside from the previously discussed hereditary cancer syndromes and genetically determined early changes of the pancreas, which are not accounting for many cases of FPC, only few other causative germ-line mutation have yet been reported in FPC: BRCA2 mutations were found to be causative for 15% of FPC in the EUROPAC study, even in the absence of breast cancer (75), for 17% of FPC as reported by the Hopkins group (76) and for 3% of FPC as proposed by the FaPaCa study (95). The gene discussed is BRCA2; the disease is breast carcinoma.