In the type 2 diabetes group, the general pattern was a small decrease followed by an almost even sized increase; however, I-AUC YKL-40 increased significantly at 1 wk (P = 0.008) and 1 yr (P = 0.007) compared to baseline, indicating an attenuation of the postprandial decrease of YKL-40. Here, CHI3L1 is linked to type 2 diabetes mellitus.