Lipoplexes based on dimethyl-hydroxyethyl-aminopropane- carbamoyl-cholesterol(DMHAPC-Chol) and dioleoyl phosphatidylethanolamine were successfully appliedto deliver siRN A targeted at mRN A of the vascular endothelial growth factor(VEGF) to A431 (human epidermoid carcinoma) and MDA-MB231 (human breast cancer)cells. The gene discussed is VEGFA; the disease is squamous cell carcinoma.