The novel findings of this study were as follows: in contrast to previous studies in which SFO lesion had minor effects on blood pressure in the AngII-salt model of hypertension (Osborn et al. 2011b), the current results showed that OVLT lesion significantly decreased basal levels of arterial pressure during high dietary salt, as well as the magnitude of the hypertensive response to AngII. This evidence concerns the gene AGT and hypertensive disorder.