AGT and hypertensive disorder: However, since it is now known that the neurogenic component of the hypertensive response to AngII is directly related to salt intake (Cowley and McCaa 1976; Osborn et al. 2003; Osborn et al. 2007; Osborn and Fink 2010), we have further investigated the contribution of these CVOs to the pathogenesis of hypertension caused by AngII administration combined with increased dietary salt (i.e., the AngII-salt model).