GLP1R and Hyperglycemia: Administration of glucagon to elevate HR in a beta-blocked patient can induce hyperglycemia (Taboulet et al. 1993), and so it should not be overlooked that OXM may have clinical value for these situations as OXM has antidiabetic properties associated with activating the GLP-1R (Maida et al. 2008; Pocai 2012).