The suppression of the hypertension following treatment with omega-3 could provide an additional mechanism for the beneficial effect of omega-3 on bone and could be explained by omega-3-induced increase in eNOS and NO bioavailability and decrease in Na+ and TGF-β1, findings which are in consistence with previous studies (Medeiros et al. 2005; Fischer et al. 2008; An et al. 2009; Chen et al. 2011). This evidence concerns the gene NOS3 and hypertensive disorder.