Furthermore, salt-loaded rats exhibited decreased renal eNOS, suggestive of reduced NO bioavailability, together with high plasma level of TGF-β1, a fibrogenic growth factor, both possibly contributing in pathogenesis of the salt-induced hypertension as well as in the apparent renal tissue and renal vascular lesions detected by histological examination. The gene discussed is TGFB1; the disease is hypertensive disorder.